منابع مشابه
Population pharmacokinetics of gentamicin in premature newborns.
OBJECTIVES To determine the pharmacokinetic parameters of gentamicin in a population of 200 premature newborns and to investigate the influence of several clinical and physiopathological covariates on the pharmacokinetics of the drug. To validate the pharmacokinetic analysis performed in another population of 50 premature newborns. METHODS A total of 200 premature newborns were evaluated at t...
متن کاملClinical Pharmacokinetics of Gentamicin in Neonates
Gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. Gentamicin is active against the majority of aerobic gram-negative bacilli such as Pseudomonas, Klebsiella and Escherichia coli. The gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. The monitoring of gentamici...
متن کاملPopulation pharmacokinetics of gentamicin and dosing optimization for infants.
The aim of this study was to characterize and validate the population pharmacokinetics of gentamicin in infants and to determine the influences of clinically relevant covariates to explain the inter- and intraindividual variabilities associated with this drug. Infants receiving intravenous gentamicin and with routine therapeutic drug monitoring were consecutively enrolled in the study. Plasma c...
متن کاملClinical Pharmacokinetics of Gentamicin
Objectives: The objectives of this study were to: (1) derive equations for estimating gentamicin clearance (Cl gent ) and volume of distribution (V d ) based on the local population attending Al-Amiri Hospital, Kuwait; (2) independently evaluate these equations by comparison with other published methods in their predictive ability to estimate Cl gent and V d . Materials and Methods: Cl gent and...
متن کاملclinical pharmacokinetics of gentamicin in neonates
gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. gentamicin is active against the majority of aerobic gram-negative bacilli such as pseudomonas, klebsiella and escherichia coli. the gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. the monitoring of gentamici...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1995
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.26.189